What is adrenal insufficiency?

What is adrenal insufficiency?

Adrenal insufficiency happens when the adrenal glands don’t produce enough cortisol and sometimes aldosterone. The production decreases when the adrenal cortex (the glands’ outer layer) is destroyed. This occurs most often when you have an autoimmune disease that causes your body to attack the glands. It can also be caused by tumors, tuberculosis and other types of infections. This condition is known as primary adrenal insufficiency.

Secondary adrenal insufficiency, which is more common than the primary form, happens because you don’t have enough of adrenocorticotropin (ACTH), the hormone secreted by the pituitary gland. If your pituitary doesn’t make enough ACTH, your adrenal glands don’t make enough cortisol.

Secondary adrenal insufficiency most often happens when you have been taking glucocorticoids (like prednisone) for an extended amount of time and then stop too quickly rather than tapering down gradually. It can also develop due to tumors in the pituitary glands pressing on the normal pituitary cells or from surgery or radiation to the pituitary gland.