What causes secondary capillary leak syndrome?

What causes secondary capillary leak syndrome?

Sepsis (a life-threatening complication of infection) most commonly causes secondary capillary leak syndrome. Other conditions that cause capillary leak syndrome include:

• Autoimmune diseases, an attack on your body’s healthy cells by your immune system.
• Differentiation syndrome, a complication of drug therapy in people with acute promyelocytic leukemia or acute myeloid leukemia.
• Engraftment syndrome, a complication that may happen after a bone marrow transplant.
• Hemophagocytic lymphohistiocytosis, a life-threatening condition caused by an overactive immune system response.
• Ovarian hyperstimulation syndrome, a complication of fertility treatment.
• Ricin poisoning.
• Snakebites.
• Viral hemorrhagic fevers, a group of infectious diseases caused by viruses.

Certain medications, including the chemotherapy drugs gemcitabine (Gemzar®) and tagraxofusp (Elzonris®), may also cause secondary capillary leak syndrome.