What causes cholangiocarcinoma?

What causes cholangiocarcinoma?

Experts don’t know exactly what causes cholangiocarcinoma. The risk factors suggest that health conditions that cause chronic (long-term) inflammation in the bile ducts may play a role in the development of this cancer. Persistent damage like inflammation can also lead to DNA changes, which may change the way certain cells grow, divide and behave. These changes probably aren’t inherited, which means parents don’t pass them to their children. Instead, the changes likely happen during a person’s lifetime.