What causes atypical depression?

What causes atypical depression?

Doctors do not know exactly why some people experience depression or atypical depression. However, theories include:

  • Impaired functioning of neurotransmitters (chemicals that carry brain signals to other parts of the body) and/or neuroreceptors (the “receivers” of the signals)
  • Genetics (having a family member with mood disorders including bipolar disorder and dysthymia [long-term depression] may also contribute to the development of atypical depression
  • Trauma
  • Stress

Additional risk factors for the development of atypical depression include:

  • Negative childhood experiences
  • Emotional, physical or sexual abuse
  • Significant illness
  • Grief following a significant loss
  • History of substance abuse

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