Is clear cell renal cell carcinoma inherited?

Is clear cell renal cell carcinoma inherited?

Having a sibling with renal cell carcinoma increases your risk of kidney cancer. Experts aren’t sure why.

Some families have genetic conditions that predispose them to clear cell renal cell carcinoma. These conditions include Von Hippel-Landau (VHL) disease and tuberous sclerosis complex. With these conditions, an inherited gene change or mutation causes cysts and tumors to form. These cysts and tumors are usually not cancerous (benign). But ccRCC can occur in these families, often at younger ages.