What is androgen insensitivity syndrome?

What is androgen insensitivity syndrome?

Androgen insensitivity syndrome (AIS) occurs when someone is genetically male but is insensitive to androgens (male sex hormones). This means the person has male sex chromosomes (one X and one Y chromosome) but may have female genitals.

AIS is a disorder of sex differentiation. It was previously called testicular feminization syndrome. It affects male fetuses as they develop in the womb, as well as sexual development during puberty. AIS prevents male genitals from developing as they should. It almost always results in infertility during adulthood.