What causes the Dupuytren's Disease?

What causes the Dupuytren's Disease?

Dupuytren’s disease is believed to be hereditary, though approximately only one patient out of four identifies a relative who has the disease. The disease occurs six times more frequently in men than in women and has the highest incidence in people with European backgrounds. However, Dupuytren’s disease has now been found in virtually all races and ethnic backgrounds. Twenty percent or fewer of individuals have a severe form of Dupuytren’s disease characterized by nodules and cords on the bottom of their feet, thickening over the tops of the finger joints (known as knuckle pads), or early onset of the disease. The disease usually occurs after age 40.