What causes amyloidosis?

What causes amyloidosis?

Amyloidosis is a “protein misfolding disorder.” Normally, proteins in the bloodstream are removed and/or recycled once they have completed their job. In amyloidosis, however, a protein can change shape (or “misfold”) and can no longer be cleared. These misfolded proteins clump together and form amyloid fibrils, which are then deposited in the spaces between the cells of vital organs. As amyloid fibrils build up in one or more tissues and organs, the cells can no longer work together and the organ(s) loses function.