What are the complications associated with alpha-1 antitrypsin deficiency (Alpha-1)?

What are the complications associated with alpha-1 antitrypsin deficiency (Alpha-1)?

Complications of Alpha-1 depend on the disease it causes:

• Lungs: If you develop lung disease, complications may include emphysema or bronchiectasis (damage to the walls of the airways in your lungs).
• Liver: If Alpha-1 causes liver disease, you may experience swelling of your abdomen and legs, have a higher risk of infections, or develop liver scarring or cancer.
• Skin: In rare cases, some people with Alpha-1 develop a skin disease called panniculitis. This condition can cause painful red lumps in the skin. The lumps may break open and discharge liquid or pus.