Is corticobasal degeneration inherited?

Is corticobasal degeneration inherited?

Medical experts don’t know why some people develop corticobasal degeneration. The condition rarely affects members of the same family.

Nine in 10 people with the condition have a gene change (mutation) on chromosome 17. Called the H1 haplotype, this gene change may increase the production of tau, causing the protein to clump together. Or it may cause a carbon atom and hydrogens (a methyl group) to stick to the tau gene, affecting its function. But this gene mutation isn’t the only factor — the same mutation is present in 3 out of 4 people in the general population.