How is AL amyloidosis treated?

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How is AL amyloidosis treated?

A doctor who specializes in blood disorders (hematologist) will create a treatment plan for you.

Treatments for patients with AL amyloidosis include various medications:

Chemotherapy drugs

  • Melphalan (Alkeran® , Evomela®).
  • Cyclophosphamide (Cytoxan®).
  • Bortezomib (Velcade®).
  • Carfilzomib (Kyprolis®).
  • Ixazomib (Ninlaro®).
  • Lenalidomide (Revlimid®).
  • Pomalidomide (Pomalyst®).

Immunotherapy drugs

  • Daratumumab (Darzalex®).

Steroid medications

  • Dexamethasone.
  • Prednisone.

Most patients take one or two chemotherapy drugs plus steroid medication. The drugs work together to destroy the plasma cells that make the light chain proteins. Your doctor may also talk to you about whether you may benefit from a bone marrow/stem cell transplant.

Medications can stop or slow the progression of AL amyloidosis but cannot remove the fibrils already in the body. A monoclonal antibody CAEL-101, designed to remove the amyloid deposits in the affected organs, is being tested in clinical trials.

Your treatment team will likely include:

Cardiologist: A doctor that specializes in the heart.

Gastroenterologist: A doctor who specializes in the gastrointestinal tract.

Hematologist: A doctor that specializes in blood problems.

Nephrologist: A doctor that specializes in the kidneys.

Neurologist: A doctor that specializes in the nerves.

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