How is AA amyloidosis treated?

How is AA amyloidosis treated?

For AA amyloidosis, treating the underlying chronic inflammatory condition is crucial to stop further amyloid deposits. For Familial Mediterranean Fever, the medication colchicine (Colcrys®, Mitigare®) is very effective as a preventative medication. Biologic agents (anti-TNFα, anti-IL-1, anti-IL-6) can be used to reduce the risk and treat active AA amyloidosis related to autoimmune and rheumatic disorders. There are many good treatment options available for other conditions such as Crohn’s disease, ulcerative colitis, and rheumatoid arthritis. As the inflammation associated with these diseases is controlled with medication, the AA amyloidosis slowly regresses.

New therapies in the research and development stage include medications that bind and clear the amyloid fibril building blocks from the blood and antibodies that target and clear amyloid fibrils that have already been deposited.