How does ALD affect the body?

How does ALD affect the body?

People with ALD can’t break down high levels of fat molecules — specifically very-long-chain fatty acids (VLCFAs). As a result, VLCFAs build up in the brain, nervous system and adrenal cortex, the largest part of the adrenal gland.

Scientists aren’t exactly sure how the VLCFA buildup affects the body. But research suggests the accumulation causes inflammation that damages the myelin sheath. Myelin is the protective layer around nerve cells in the brain.

When myelin is damaged, nerve cells cannot send signals from the brain to the body. This causes problems with the body’s functions, including how you move and think.

People with ALD have shortages of some hormones because ALD also damages the adrenal glands. The adrenal glands sit on top of each kidney. They make hormones that affect male and female sex characteristics and your stress response.