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Your doctor may order various tests depending on what type of connective tissue disorder is suspected. The doctor will first ask for your medical history, a family history, and will do a physical examination. Further tests may include:

  • Imaging tests, such as X-rays and magnetic resonance imaging (MRI) scans.
  • Tests for markers of inflammation, such as C-reactive protein and Erythrocyte sedimentation rate (ESR).
  • Tests for antibodies, especially for autoimmune conditions.
  • Tests for dry eyes or dry mouth.
  • Blood and urine tests.
  • Tissue biopsy.

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