Dubin-Johnson syndrome and Rotor syndrome are both genetic conditions that share similar symptoms of jaundice. The main difference between both conditions is the cause. A genetic mutation of the ABCC2 gene causes Dubin-Johnson syndrome. A genetic mutation of the SLCO1B1 and SLCO1B3 genes cause Rotor syndrome. Rotor syndrome can also significantly affect how your body handles certain medications, so it’s very important that your doctor knows that you or your child has Rotor syndrome before prescribing certain medications.
In addition, Rotor syndrome doesn’t cause the color of your liver to change, whereas people diagnosed with Dubin-Johnson syndrome have a black liver.