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Lymphoma is the most frequent form of blood cancer, occurring when lymphocytes (a type of white blood cell) multiply uncontrollably. The two main kinds of lymphocytes that develop into lymphomas are B-cells and T-cells.

CTCL is a general term for T-cell lymphomas that affect the skin. There are three main subtypes:

  • Mycosis fungoides: The most frequent type of CTCL (50 percent of all cases), it usually involves only the skin and grows slowly over many years.
  • S├ęzary syndrome: The second most common type of CTCL (15 percent of all cases). Lymphoma cells are found in both the skin and the bloodstream.
  • CD30-positive lymphoproliferative disorders: This type includes a wide range of CTCLs, some of which can grow very quickly.
Lymphocytes develop into B-cells and T-cells. CTCL, or cutaneous T-cell lymphoma, is a term for rare lymphomas affecting the skin. There are three types, with a total of some 3,000 new cases per year in the United States.