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When your healthcare provider suspects Cushing’s syndrome, he or she will look at your medical history, perform a physical examination and then conduct some laboratory tests.

Cushing’s syndrome can sometimes be difficult to diagnose. If someone reports fatigue and weight gain, that doesn’t point straight at Cushing’s syndrome. It’s also sometimes mistaken for polycystic ovary syndrome or metabolic syndrome. Your healthcare provider will have to go through a process of elimination to rule out other conditions.