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There are many things that can cause crystals to form in urine. They include:

  • Dehydration (not drinking enough water).
  • Eating large amounts of certain foods, including protein, salt, fruits and vegetables.
  • Medications such as amoxicillin, acyclovir, sulfonamides, atazanavir and methotrexoate.
  • Urinary tract infections.
  • Ethylene glycol poisoning.
  • Having tumor lysis syndrome, which is caused by the death of a large number of cancer cells. This may happen as a result of cancer treatment.