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Treatment of cryoglobulinemia is not always necessary and depends on the organs affected, degree of damage, and presence of other medical conditions. It is very important not only to treat the cryoglobulinemia but also to address any other associated disorders.

The mainstay of treatment is corticosteroids with or without other medications depending on the affected organ and the extent of involvement.

Another form of treatment decreases the amount of cryoglobulins in the blood. This procedure, called plasmapheresis, removes cryoglobulins from the plasma (the liquid in the blood). This helps prevent cryoglobulins from clogging the arteries, which blocks blood flow and could lead to the rash and organ damage.

If another medical condition has been found, such as hepatitis C, anti-viral therapy may be recommended, often with referral to a hepatologist (liver specialist).

If multiple myeloma or lymphoma is found, a referral to a hematologist is recommended.

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