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The most common symptom of chronic limb-threatening ischemia is an intense foot or leg pain. Often, this pain wakes you up at night. You may hang your leg off the edge of your bed or get up and walk around to relieve the pain. Some people don’t feel any pain, but notice other symptoms like the following:

  • Cold hands, feet or legs.
  • Feet that appear smooth, shiny, hairless or very dry.
  • Weak or no pulse in your legs or feet.
  • Numbness in your legs, feet or hands.
  • Slow-healing sores on your feet or legs.
  • Skin discoloration or discharge from gangrene.
  • Thick toenails.