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Studies show that a liver transplant could cure Crigler-Najjar syndrome. During a liver transplant, a healthy donor’s liver replaces your liver during a lengthy surgical procedure. The outcome of a liver transplant for a person diagnosed with Crigler-Najjar syndrome is to prevent life-threatening symptoms like brain damage from occurring. As the cells and enzymes in your liver can’t break down bilirubin, replacing your liver with a liver that can break down bilirubin is an effective treatment option.