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Children diagnosed with Crigler-Najjar syndrome type 2 will have a good prognosis if their condition receives treatment early to prevent life-threatening symptoms.

Severe cases of Crigler-Najjar syndrome type 1 have a poorer prognosis if the condition isn’t diagnosed and treated within the first few months of life. In these cases, children are at risk of life-threatening symptoms that prevent them from living beyond two years.

Most people diagnosed with Crigler-Najjar syndrome will need lifelong treatment and management of the condition. With effective treatment, they’ll have a normal lifespan.