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Signs of corticobasal degeneration typically appear when you’re in your 60s. Some people show symptoms as early as in their 40s.

The disease affects everyone differently. It often first occurs on one limb or one side of your body and then progresses to the rest of your body. Symptoms worsen as the disease affects more of your brain.

Corticobasal degeneration symptoms include:

  • Balance problems and uncoordinated walking gait.
  • Difficulty swallowing.
  • Memory problems.
  • Muscle spasmsmuscle twitches (myoclonus) and muscle contractions (dystonia).
  • Trouble completing tasks like using utensils or buttoning a shirt.
  • Difficulty coordinating fine movements (apraxia).
  • Difficulty controlling one limb (alien limb syndrome) and slowed movements (bradykinesia).
  • Dementia.
  • Slurred or slow speech or difficulty finding the right words (aphasia).
  • Tremors.


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