Researchers currently think corticobasal degeneration is a form of frontotemporal degeneration and distinct from Alzheimer’s disease. The breakdown of cells here affects your brain’s frontal and temporal lobes.
The condition occurs when a tau, a protein normally found in brain cells, abnormally clumps together. These clumps, or neurofibrillary tangles, cause your brain cells to degenerate or die. This leads to problems with movement, speech and memory.